This research was performed to characterize the neuroprotective effect of methanolic leaf extract of Ficus religiosa Linn (MEFR) on alloxan induced diabetic neuropathy in rats. Experimental diabetes was induced in wistar albino rats by single intraperitoneal injection of alloxan monohydrate (150 mg/kg). The methanolic extract of leaves of Ficus religiosa at a dose of 200 and 400 mg/kg body weight was administered at single dose per day to diabetes induced rats for a period of 28 days. During the treatment period neuropathic pain was assessed in diabetic rats with various painful procedures to assess the degree of thermal, mechanical, cold hyperalgesia and locomotor activity as well as motor co-ordination. The plant extract at 200 and 400 mg/kg significantly restored the reduced body weight and attenuated behavioural alterations. From this study we conclude that methanolic leaf extract of Ficus religiosa exhibits significant neuroprotective activities against alloxan-induced diabetic neuropathy in rats.
Loading....